Analgesic, Anti-inflammatory, and Anti-pyretic Activities of Crinum pedunculatum R.Br. Bulb Extracts

Pharmacognosy Research,2022,14,1,24-29.DOI:10.5530/pres.14.1.5Published:December 2021Type:Original ArticleAuthors:Peace Doe, Cynthia Amaning Danquah, Kwasi Adomako Ohemeng, Ako Ernest Opare, Ahmed Sharif, Dorcas Akua-Abora, Asamoah Kwame Akuoko, Aaron Kpabitey, Emmanuel Quarshie, Oliver Opoku Asante, Elvis Kwadwo Amponsah, Mariyana Mutwaliku, Charlotte Nuro-Brefo, and Micheal Ofori Author(s) affiliations:Peace Doe1,2,*, Danquah1, Ohemeng3, Opare2, Sharif2, Akua-Abora2, Akuoko2, Kpabitey2, Quarshie2, Asante2, Amponsah2, Mutwaliku2, Nuro-Brefo2, Ofori1 1Department of Pharmacology, Faculty Pharmacy Pharmaceutical Sciences, Nkrumah University Science Technology, GHANA. 2Department School Pharmacy, Central University, 3Department Medicinal Chemistry, Abstract:Background: Crinum pedunculatum R.Br. bulbs are used for the topical management inflammation by traditional healers in southern region Ghana. Objectives: This study aims to assess analgesic, anti-inflammatory, anti-pyretic activities different solvent extracts pedunculatum. Methods: The bulb were determined rats at doses 100, 200, 400 mg/kg. acetic acid induced writhing test was determine analgesic activity, carrageenan employed anti-inflammatory Brewer’s yeast-induced pyrexia studied evaluate extract’s activity. Results: All significantly decreased (P < 0.001) frequency all with mg/kg ethanolic extract showing a 98% inhibition comparable that obtained diclofenac sodium 94%. These also caused increase paw diameter administration ethyl acetate causing 97% oedema. (100, mg/kg) methanol significant decrease 0.0001) temperature via yeast ethanol showed reduction rectal temperature. Conclusion: results indicate methanolic, ethanolic, possess antipyretic activities. Keywords:Analgesic, Anti-inflammatory, Anti-pyretic, pedunculatum, Rats.View:PDF (373.01 KB) Full Text